Eosinophils Bolster Maternal Intestinal Immunity During Reproduction
Maternal immunity must protect the fetus while preserving intestinal defense; new research reveals how eosinophils reinforce mucus production during and after reproduction.
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FGFR2c-TRPA1 Lipid Raft Signaling In PDAC Progression
Research links FGFR2c, TRPA1, and cholesterol-rich lipid rafts to oncogenic signaling, epithelial-mesenchymal transition, and invasive behavior in pancreatic ductal adenocarcinoma.
An Immune Evasion Mechanism in Disseminated Tumor Cells
A glucocorticoid receptor program suppresses FAS-dependent immune clearance, helping disseminated tumor cells survive early metastatic colonization and resist cytotoxic lymphocytes.
New Insights into Neuroendocrine-Tuft Lineage Plasticity in Small Cell Lung Cancer
Basal lung cells can generate neuroendocrine and tuft-like tumor states, revealing mechanisms that shape lineage plasticity and heterogeneity in small cell lung cancer.
Wide-ranging Neuromuscular Effects of C9orf72 Loss in ALS
C9orf72 loss disrupts Schwann cell function, peripheral myelination, and neuromuscular junction stability, broadening the role of glial and immune dysfunction in ALS.
ECM Stiffening Links Testicular Aging and Testosterone Decline
Age-related extracellular matrix stiffening impairs stem Leydig cell function and testosterone production through Piezo1-dependent mechanotransduction and mitochondrial stress.
PFKL is an Epigenetic Factor that Enhances HDACi Activity in Solid Tumors
PFKL acts beyond glycolysis as an epigenetic regulator that strengthens HDAC inhibitor activity and may help overcome treatment resistance in solid tumors.
Fibrin Gel-Induced YAP Inactivation/MafG Derepression Elicits CAR T Cell Stemness
Mechanical signals from 3D fibrin gels decouple proliferation from differentiation, enabling scalable expansion of persistent stem-like CAR T cells for solid tumors.
Microbiota Metabolite TDCA Sustains Intestinal ILC Residency via P2Y10
The microbiota-derived bile acid TDCA activates P2Y10 signaling to retain innate lymphoid cells in intestinal tissue and strengthen mucosal protection.
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